Thioredoxin-interacting protein txnip

Author: xwin

August undefined, 2024

Web结果. 与空白对照组比较，lps模型组细胞发生了一定的应激反应，出现线粒体自噬，但部分炎症因子表达受限，与细胞功能受损有关，表现为ho-1、il-1β、lc-3b、ros的蛋白表达均明显升高，而tnf-α、txnip、nlrp3的蛋白表达均明显降低，说明lps攻击后细胞受损严重，模型制备成 … WebThioredoxin-interacting protein (TXNIP) is an endogenous inhibitor of thioredoxin (Trx), and it acts by inhibiting its reducing capacity, thereby promoting cellular oxidative stress. In addition, it participates in regulating multiple signaling pathways as a member of the α-arrestin family of proteins. Accumulating evidence suggests that TXNIP ...

Role of Thioredoxin-Interacting Protein in Diseases and …

WebMar 21, 2024 · Thioredoxin-interacting protein (TXNIP, also called thioredoxin binding protein 2 or vitamin D upregulated protein), was originally identified as a negative regulator of thioredoxin which is a ... WebJan 23, 2024 · Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism. Kokubo K, et al. Proc Natl Acad Sci U S A, 2024 Jan 10. PMID 36595680, TXNIP Promotes Human NK Cell Development but Is Dispensable for NK Cell Functionality. Persyn E, et al. Int J Mol Sci, 2024 Sep 26. marriott property support phone number

Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and

WebThioredoxin interacting protein (TxNIP) functions as an effector of glucotoxicity in pancreatic β-cells. Exendin-4 (Ex-4), a long-term effective GLP-1 receptor agonist, reduces TxNIP level in pancreatic β-cells. Mechanisms underlying this reduction, however, remain largely unknown. We show here that Ex-4, 8-bromo-cAMP, the cAMP promoting ... WebThioredoxin-interacting protein (TXNIP), also known as thioredoxin-binding protein 2 (TBP-2)/vitamin D3up-regu-latedprotein1(VDUP1),isanα-arrestinthatcanbindtoand inhibit … WebThioredoxin-interacting protein (TXNIP) is a metabolic control protein that regulates cellular glucose uptake. TXNIP is a member of the alpha arrestin protein superfamily and serves as a tumor suppressor gene. A well known function of TXNIP is that TXNIP binds covalently to thioredoxin; this both inhibits thioredoxin’s ability to scavenge ROS ... marriott public relations

Thioredoxin-Interacting Protein in Cancer and Diabetes

WebWhen unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulum (ER), intracellular signaling pathways called the unfolded protein response … WebNov 30, 2024 · Thioredoxin interacting protein (Txnip) is an α-arrestin protein that regulates pleiotropic biological responses. Txnip acts as a cancer suppressor and is a critical … marriott providence downtown rhode islandWebMay 1, 2005 · THIOREDOXIN-INTERACTING PROTEIN (TXNIP) was first isolated from a 1,25-dihydroxyvitamin D3-treated HL-60 human promyelocytic cell line and therefore called vitamin D3-up-regulated gene 1 (VDUP1) (1– 3).TXNIP binds to and inhibits thioredoxin and thereby modulates the cellular redox state (3, 4).The thioredoxin system reduces oxidized … marriott public sector

"WebThioredoxin interacting protein (Txnip) is one of such inhibitors (16) that restrains the function of thioredoxin 1, which is a major intracellular antioxidant (14). An in vitro study … " - Thioredoxin-interacting protein txnip

Thioredoxin-interacting protein txnip

10628 - Gene ResultTXNIP thioredoxin interacting protein [ (human)]

WebJul 2, 2024 · Thioredoxin-interacting protein (TXNIP), also known as thioredoxin-binding protein-2 or vitamin D3-upregulated protein 1, has been shown to be an endogenous antagonist of the antioxidant protein thioredoxin (Trx) (Zhao et al., 2024b). WebMar 9, 2024 · Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, …

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WebApr 10, 2024 · Introduction. Our previous study has proofed the glucose sensitive gene-thioredoxin-interacting protein (TXNIP) expression was up in the placenta of the patients with gestational diabetes mellitus (GDM), but the pathological mechanisms underlying abnormal TXNIP expression in the placenta of patients with GDM is completely unclear … WebOct 4, 2007 · Thioredoxin-interacting protein (Txnip), also known as thioredoxin binding protein 2 or vitamin D 3 upregulated protein 1, probably interacts with thioredoxin via a disulfide bond, reducing thioredoxin activity. 4 Mechanical or oxidative stress suppresses Txnip expression without affecting thioredoxin expression, leading to a net increase in ...

WebNov 11, 2024 · The development of new therapeutic approaches to diseases relies on the identification of key molecular targets involved in amplifying disease processes. One such … WebApr 10, 2024 · Introduction. Our previous study has proofed the glucose sensitive gene-thioredoxin-interacting protein (TXNIP) expression was up in the placenta of the patients …

WebJul 29, 2024 · Thioredoxin‐interacting protein (TXNIP) is associated with activation of oxidative stress through inhibition of thioredoxin (Trx). However, some evidences point out that TXNIP acts as a scaffolding protein in signaling complex independent of cellular redox regulation. The autophagy‐lysosomal pathway plays important roles in the clearance of ... WebTXNIP is a promising NAFLD biomarker that offers an efficient way to evaluate and monitor fatty liver progression among patients with T2DM. Keywords: thioredoxin-interacting …

WebJun 26, 2009 · Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of antioxidant thioredoxin (TRX), plays a causative role in diabetes and its vascular complications. Herein we investigate whether HG and RAGE induce inflammation in rat retinal endothelial cells (EC) under diabetic conditions in culture through TXNIP activation …

WebFeb 15, 2024 · Thioredoxin interacting protein (TXNIP) was first isolated from HL-60 cells after vitamin D3 treatment and named vitamin D3 upregulated protein 1 (VDUP1) [4]. Subsequently, it was identified as a kind of protein binding to thioredoxin (TRX) that inhibits the redox function of TRX [5]. TXNIP was confirmed to play a vital role in the homeostasis ... marriott pulse nyc phone numberWebNov 11, 2024 · The development of new therapeutic approaches to diseases relies on the identification of key molecular targets involved in amplifying disease processes. One such molecule is thioredoxin-interacting protein (TXNIP), also designated thioredoxin-binding protein-2 (TBP-2), a member of the α-arrestin family of proteins and a central regulator of … marriott provisioning toolWebMar 19, 2014 · Western blot analysis and immunohistochemistry (IHC) were used to assess thioredoxin interacting protein (TXNIP) expression in thyroid cancer cell lines and primary tumor specimens. Retroviral transduction was used to generate ATC cell lines that overexpress TXNIP, and assays that assess glucose uptake, viable cell proliferation, and … marriott providence downtown ri