WebSMARCA2 Inhibitor Screening, BioAssay™ Kit (SMARCA2, BRM, BRG1-Associated Factor 190B, SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin 2, … WebJul 23, 2024 · A common technique to study a protein and its functions is to remove or deactivate it in cells using genetic knockout or knockdown, for example, using techniques …
SMARCA2 TR-FRET Assay Kit from BPS Bioscience, Inc.
WebFull length recombinant human SMARCA2 Remodeling Enzyme. SMARCA2 is a core ATPase subunit of the ATP-dependent chromatin remodeling complex SWI/SNF that mobilizes nucleosomes and plays key roles in … WebDec 16, 2024 · TR-FRET is an assay method that requires the labeling of a donor molecule with a long lifetime fluorophore (e.g. Europium) and the labeling of an acceptor molecule with a short-lived fluorophore (e.g. APC or Cy5). There must be overlap of the donor emission and the acceptor excitation spectra for energy transfer (FRET) to occur. small changes solihull
EpiDyne FRET-based Chromatin Remodeling Assay Substrate
WebKey components of this complex are the mutually exclusive ATPase subunits SMARCA2 and SMARCA4, 30 which are promising targets for therapeutic intervention in cancers based on genetic knockdown studies. 31 Interestingly, bromodomain (BD) inhibitors of SMARCA2/4 are not antiproliferative, suggesting that chromatin remodeling can occur irrespective … WebHTRF is a FRET-based technology that emerged from the Jean-Marie Lehn ’s Nobel prize-winning work on rare earth complexes. Due to the chemical and photophysical characteristics of these fluorescent dyes, HTRF exhibits performance levels in stability and specificity that make it unparalleled for time-resolved FRET studies. WebMar 21, 2024 · SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2) is a Protein Coding gene. Diseases associated with … some sheets