WebAbstract Pulmonary fibrosis (PF) is a heterogeneous disease with a poor prognosis. Therefore, identifying additional therapeutic modalities is required to improve outcome. However, the lack of biom... An Integrative Multiomics Framework for Identification of Therapeutic Targets in Pulmonary Fibrosis - Arif - Advanced Science - Wiley Online Library WebApr 10, 2024 · (a) Confocal microscopy of RAW 264.7 cells treated without (vehicle only) or with 300 nM or 3 μM C3larvinA‐DyLight‐488 and incubated for 5 h at 37°C prior to being fixed and stained with...
Zebrafish mafbb Mutants Display Osteoclast Over-Activation
WebOct 12, 2014 · Mechanistic studies revealed that WNT16 is osteoblast derived and inhibits human and mouse osteoclastogenesis both directly by acting on osteoclast progenitors … WebNov 18, 2012 · Bone-resorbing osteoclasts are formed from a monocyte/macrophage lineage under the strict control of bone-forming osteoblasts. So far, macrophage colony … the source west edmonton
Epigenetic and transcriptional regulation of osteoclast …
WebAmong these, we identified MAFB [ 44] and WNT1 [ 45, 46] which have been reported to be pivotal modulators of bone remodeling through the regulation of osteoclasts [ 44] and osteoblasts [ 47] differentiation, respectively, thus suggesting a potential role for miR-148a in the regulation of bone resorption and deposition in physiologic conditions … WebMar 23, 2024 · In this study, we generated zebrafish MAFB homolog mafbb mutant utilizing CRISPR/Cas9 technology. Mafbb deficient zebrafish demonstrated enhanced osteoclast … WebApr 15, 2007 · Herein, we present evidence that MafB has dual roles as a repressor of osteoclastogenesis as well as an inducer of macrophage differentiation, suggesting that … myrtlewood condos allow pets