Web7 de set. de 2024 · Artificial polymers, like antibiotic peptides, need both hydrophobic and hydrophilic domains in their molecular structure to exert antibacterial activity. Now, researchers from Canada have synthesized a phosphonium polymer that challenges this view. As outlined in the journalAngewandte Chemie, their polymer salt contained no … Web15 de jul. de 2024 · Herein, we report the design of a focused library of novel bacterial topoisomerase inhibitors (NBTIs) based on innovative mainly monocyclic right-hand side fragments active against DNA gyrase and Topo IV. They exhibit a very potent and wide range of antibacterial activity, even against some of the most concerning hard-to-treat …
Synthesis and Bioactivities of New Membrane-Active Agents with …
Web26 de ago. de 2024 · The obtained polypeptoid sulfoniums, with high selectivity and potent antibacterial property, are excellent candidates for antibacterial treatment and open up new possibilities for the preparation of a class of innovative antimicrobials. Open Research Supporting Information Volume 33, Issue 41 October 14, 2024 2104402 Download PDF WebThe antibacterial and cytotoxicity studies showed that the selectivity index for SAAP-148 NPs was drastically increased, by 10-fold, regarding AMR Staphylococcus aureus and 20-fold regarding... t-shirts herren bedruckt
Antimicrobial activity, improved cell selectivity and mode of …
WebSun, J., Li, M., Lin, M., Zhang, B., & Chen, X. (2024). High Antibacterial Activity and Selectivity of the Versatile Polysulfoniums that Combat Drug Resistance. Web26 de ago. de 2024 · Sulfonium-ion-containing polymers exhibit significant potential benefits for various applications. An efficient strategy to synthesize a type of antibacterial sulfonium-ion-bearing polypeptoids via a combination of ring-opening polymerization and a post-polymerization functionalization with various functional epoxides is presented. Web8 de jun. de 2024 · Antimicrobial peptides (AMPs) have been recognised as a significant therapeutic option for mitigating resistant microbial infections. It has been found recently that Plasmodium falciparum-derived, 20 residue long, peptide 35409 had antibacterial and haemolytic activity, making it an AMP having reduced selectivity, and suggesting that it … t shirts herren gute qualität