Dihydro crytotanshinone
WebMar 1, 2024 · Visit ChemicalBook To find more Dihydrotanshinone(20958-18-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of … WebCN-1944455-A chemical patent summary.
Dihydro crytotanshinone
Did you know?
WebMay 15, 2012 · Free Online Library: Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes.(Report) by "Phytomedicine: International Journal of Phytotherapy & Phytopharmacology"; Health, general Biological sciences Science and technology, … WebJan 1, 2009 · Cryptotanshinone was colocalized with STAT3 molecules in the cytoplasm and inhibited the formation of STAT3 dimers. Computational modeling showed that cryptotanshinone could bind to the SH2 domain of STAT3. These results suggest that cryptotanshinone is a potent anticancer agent targeting the activation STAT3 protein.
WebJan 15, 2014 · Abstract. Crytotanshinone (CTN), one of the main constituents of tanshinones, has been reported to exhibit anti-tumor, anti-inflammatory and other important therapeutic activities. The aim of this study was to investigate the potential therapeutic effects of CTN on murine model of lipopolysaccharide (LPS)-induced acute lung injury (ALI). WebProduct Description. Cryptotanshinone is a natural quinoid diterpene first isolated from Salvia miltiorrhiza roots, which are used in traditional Chinese medicine for a variety of conditions. 1 Cryptotanshinone, at 10-20 µM, stimulates AMP-activated protein kinase in C2C12 myotubes and activates p38 MAPK in DU145 cells. 2, 3 It inhibits the ...
WebThe present invention relates to use of Cryptotanshinone represented by formula (I): or a pharmaceutical composition containing the compound for manufacturing drug in preventing and treating early stage AD. ... HYXITZLLTYIPOF-UHFFFAOYSA-N 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound … WebDihydrotanshinone I and cryptotanshinone exhibit strong inhibition towards human liver microsome (HLM)-catalyzed propofol glucuronidation, and dihydrotanshinone I exhibits stronginhibitiontowardsUDP-glucuronosyltransferase(UGT)1A7.[7,8] Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post ...
WebApr 9, 2024 · Cryptotanshinone (CTN) has shown its neuroprotective and anti-inflammatory qualities in non-genetic mouse model of Alzheimer’s disease. According to bioinformatics analysis, CTN and Signal Transducer and Activator of Transcription 3 (STAT3) may interact to form a drug-target network. This study was conducted to identify …
WebOct 6, 2024 · The related molecule cryptotanshinone 4 displayed broadly similar anti-inflammatory effects, although this compound also decreased initial neutrophil recruitment. However, no other tanshinones have been investigated in this manner, meaning that no knowledge of any analogous effects of tanshinones based on TI 1 currently exists in the … build last epochWebCryptotanshinone (CTS), tanshinone IIA (Tan IIA), dihydrotanshinone I (diTan I), and tanshinone I (Tan I) are the main active compounds in the liposoluble extract of Salvia miltiorrhiza. The differences in the pharmacokinetic and tissue distribution behaviors of the four tanshinones after oral administration of the liposoluble extract of Salvia ... build laptop shellWebJun 23, 2012 · Dihydrotanshinone I "Total Synthesis of Dan Shen Diterpenoid Quinones", R. L. Danheiser, D. S. Casebier, and J. L. Loebach, Tetrahedron Lett. 1992, 33, 1149. [ Home ... build laptop table